They identified seven significantly downregulated genes that encode for ligand gated p2 purinoreceptors, including P2rx3, Prx4, and P2rx7. They showed that EVI1 binds to three different sites within the P2rx7 promoter region and significantly downregulates P2rx7 transcription in AML [78]. This evidence concerns the gene RUNX1 and acute myeloid leukemia.