The first fifteen genes that were significantly hypomethylated on different sites across the genome in cancer tissues in comparison to control healthy tissues, named ATXN1, PPP2R2C, CCR6, RAB37, DUSP27, ZNF521, SLC6A17, SPIN1, CXCR1, SPTBN1, NBAS, NRG3, COL5A1, CDX1, and BATF3 are mostly involved in transcriptional and immune regulation. This evidence concerns the gene SPTBN1 and cancer.