ITPR3 and cancer: Thus, the top fifteen significantly hypermethylated sites in cancer tissues in comparison to healthy tissues are: LMBR1L, CDH1, EIF6, C16orf70, ETNK2, C11orf73, ADARB2, GAB1, ITPR3, WDR61, PGAP2, DDX10, DGKH, RAB40C, and BEAN1 genes (Table 3).