The top fifteen genes significantly hypermethylated in their promoters in cancer tissues in comparison to healthy tissues are: GPRC5D, TMPRSS11B, PIAS2, ARG1, SRPK2, AADACL2, RGPD4, SPRR3, DEGS1, TXNDC8, SH3TC1, ZPLD1, FBXO2, ATG16L1, and GRHL1 (Table 1). This evidence concerns the gene SPRR3 and cancer.