The first fifteen genes that were significantly hypomethylated on different sites across the genome in cancer tissues in comparison to control healthy tissues, named ATXN1, PPP2R2C, CCR6, RAB37, DUSP27, ZNF521, SLC6A17, SPIN1, CXCR1, SPTBN1, NBAS, NRG3, COL5A1, CDX1, and BATF3 are mostly involved in transcriptional and immune regulation. The gene discussed is COL5A1; the disease is cancer.