The top fifteen significantly hypermethylated genes, named LMBR1L, CDH1, EIF6, C16orf70, ETNK2, C11orf73, ADARB2, GAB1, ITPR3, WDR61, PGAP2, DDX10, DGKH, RAB40C, and BEAN1 on different gene sites (mostly in 5′UTR and body) in cancer tissues in comparison to control healthy oral tissues are mostly involved in translational processes and cellular growth, along with transformation and proliferation. This evidence concerns the gene PGAP2 and cancer.