Recent studies have shown that there is a significant cross-talk between Hh signaling pathway and other signaling pathways, including Wnt, Notch, EGFR, p53, PI3K/mTOR, and vitamin D. A further argument for the involvement of other pathways in the development of BCC could be the tumor resistance to Hh inhibitors. Here, MTOR is linked to skin basal cell carcinoma.