Abdelbaset et al., for example, designed several thieno[2,3-b]quinoline-2-carboxamide-chalcone derivatives, as molecule 54 (Figure 26a) that showed significant antiproliferative effects against tested cancer cell lines (IC50 values in the range 0.9–1.2 μM) and an EGFR IC50 = 0.5 μM. This evidence concerns the gene EGFR and cancer.