PTH and Marchiafava-Bignami disease: By definition, CKD-MBD is a systemic disorder of mineral and bone metabolism, which is manifested by either one or a combination of the following: abnormalities of calcium, phosphorus, parathyroid hormone (PTH), or vitamin D metabolism; abnormalities in bone turnover, mineralization, volume, linear growth, or strength; vascular or other soft tissue calcification [2].