Moussallieh et al. 2014 utilized proton High Resolution Magic Angle Spinning NMR spectroscopy (1H-HRMAS NMR) in order to compare sera from 44 NMO patients (22 AQP4-IgG+ and 22 AQP4-IgG−) with 47 RRMS patients and 42 healthy controls [85]; however, the reported results did not differentiate between AQP4-IgG+ and AQP4-IgG− NMO. The gene discussed is AQP4; the disease is neuromyelitis optica.