Some of these genes may be of particular interesting in the thyroid; for instance, Arid2 was shown to be mutated in poorly differentiated and anaplastic thyroid cancer [48], and Akirin 2 is emerging as a novel player in the NF-κΒ-driven immune/inflammatory response [49]. Here, AKIRIN2 is linked to thyroid gland undifferentiated (anaplastic) carcinoma.