In the last few years, a role of Nrf2 in thyroid physiology and pathophysiology has emerged [7]; Nrf2 upregulates Tg transcription [2] through AREs in a Tg enhancer [2,8], downregulates Tg iodination [2], and is activated in response to iodide exposure [2,9], as well as in thyroid carcinomas [10,11,12]. This evidence concerns the gene NFE2L2 and thyroid gland carcinoma.