Recent evidence showed that TGF-β1 can also upregulate STAT3 in PAH (Cai et al., 2018), suggesting that there might be a relationship between released miRNA-204 and miRNA-let-7a and a decrease in miRNA-214-3p, which would be reflected in the reversal of increased c-fos expression. This evidence concerns the gene STAT3 and pulmonary arterial hypertension.