In contrast, when PBMCs were incubated with a variety of high grade serous ovarian adenocarcinoma cell lines, including OVCAR8, OVCAR3, and OVCAR5, robust NK cell degranulation and intracellular IFNγ production was seen compared to no treatment and rhIL-15 alone (Figure 3A–C). The gene discussed is IFNG; the disease is ovarian serous adenocarcinoma.