While metastatic prostate cancer patients displayed a slight decrease in NK cell activity, when compared to normal donors, the cam1615B7H3 TriKE enhanced degranulation and IFNγ production, in both normal donor and patient NK cells, against C4-2, DU145, LNCaP and PC3 prostate cancer adenocarcinoma cell lines when compared to the controls (Figure 4A–D). The gene discussed is IFNG; the disease is metastatic prostate carcinoma.