It also inhibited the phosphoinositide 3-kinases/protein kinase B/ mechanistic target of rapamycin (PI3K/Akt/mTOR) pathway, associated with the downregulation of the expression levels of matrix metalloproteinase-2 (MMP-2) in the A549 human lung carcinoma cell line [176]. The gene discussed is MTOR; the disease is lung carcinoma.