NFKB1 and carcinoma: Several phaeophytins, such as porphyrinolactone (129), 20-chlorinated (132-S)-hydroxyphaeophytin A (130), (132-S)-hydroxyphaeophytin A (131) and B (132), and (132-R)-hydroxyphaeophytin A (133) and B (134) (Figure 21) were isolated from a marine green algae Cladophora fascicularis. The antiproliferative activity was characterized by inhibition of the activation of NF-κB in the HeLa carcinoma cell line by inhibiting the TNF-α-induced NF-κB translocation from the cytoplasm into the nucleus [217].