Moreover, TAT-FADD targets NF-κB signaling to suppress the expression of anti-apoptotic genes Bcl2, cIAPs, RIP1, and cFLIPL in cancer cells, and TAT-FADD abolishes NLRP3 inflammasome transcriptional priming and processing of IL-1β in colon carcinoma HCT116 cells. Here, FADD is linked to cancer.