The stem cell transcription factor Sox2, a supposed marker for cancer stem cells and highly expressed in osteosarcoma [110], downregulates the Hippo activators merlin (Nf2) and WW domain-containing protein 1 (WWC1) and upregulates the Hippo suppressor Yes-associated protein 1 (YAP) [109]. The gene discussed is WWC1; the disease is osteosarcoma.