Along these lines, overexpression of microRNA (miRNA) 140 (miR-140), which was associated with chemosensitivity in osteosarcoma tumour xenografts, was found to induce p53 expression and G1/G2 arrest in osteosarcoma cell lines with wild-type p53 (U2-OS) but less in cell lines with mutated p53 (MG-63) [356]. Here, TP53 is linked to osteosarcoma.