An in vitro study attempting to elucidate the role of apoptosis-related proteins in osteosarcoma found that inhibition of antiapoptotic Bcl-2 using lentivirus-mediated RNA interference increases doxorubicin sensitivity in a doxorubicin-resistant MG-63 cell line, which correlated with increased levels of apoptosis [346]. The gene discussed is BCL2; the disease is osteosarcoma.