Instead, he was treated with celecoxib, a cyclo-oxygenase 2 (COX2) inhibitor, and thalidomide, which is thought to inhibit tumour angiogenesis [218], perhaps via a COX2-dependent mechanism [217], though some suggest that it may promote tumour degradation via an angiogenesis-independent COX2-related mechanism [219]. Here, PTGS2 is linked to neoplasm.