Overexpression of the genes encoding prohibitin (an antiproliferative protein) and rhoA (involved in apoptosis) decreased drug sensitivity to approximately 52% and 59%, respectively, in the Saos-2 osteosarcoma cell line due to inhibition of apoptosis [341], illustrating the importance of apoptosis in osteosarcoma chemosensitivity. The gene discussed is RHOA; the disease is osteosarcoma.