In a post-hoc analysis of the VICTOR trial that failed to show efficacy of rofecoxib for mutated PIK3CA and PIK3CA wild type stage II–III tumors, the recurrence rate was lower in aspirin-treated patients in the PIK3CA mutated tumor subgroup, supporting the prospective investigation of adjuvant aspirin in PIK3CA-mutant patients [57]. The gene discussed is PIK3CA; the disease is neoplasm.