PI3K pathway was strongly activated in PTX-resistant HeLa and ME180 cell lines established from metastatic sites of cervical cancer compared to parental cells, and the combination of PTX and a PI3K inhibitor revealed a synergistic antiproliferative activity by enhancing PTX–induced S and G2/M arrest in PTX-resistant cell lines [130]. The gene discussed is PIK3CA; the disease is cervical cancer.