RUNX3 and colorectal cancer: In breast [13] and colorectal cancer [20] Runx2 (Runt-related transcription factor 2) was found among ITGBL1 co-expressed genes, and functional studies demonstrated its role in transcriptional regulation of ITGBL1. In our microarray data, we observed several RUNX2 related pathways when using Reactome online software, e.g., “RUNX2 regulates genes involved in cell migration”, “RUNX3 Regulates Immune Response and Cell Migration”, “Transcriptional regulation by RUNX2”.