The study found that phosphatase and tensin homologue (PTEN), phosphoinositide 3-kinase (PI3K), protein kinase B (AKT), wingless-related integration site (Wnt) and β-catenin may play important roles in the development and progression of breast cancer, and they can be used as potential prognostic biomarkers. The gene discussed is AKT1; the disease is breast carcinoma.