For example, a high CD44 expression was a poor prognostic factor for breast carcinoma [39], lymphoma [40] and thymoma [41], while, in other studies, a loss/reduced CD44 expression was correlated to a poorer prognosis, such as carcinoid tumour [42], gastrointestinal stroma tumour [43], laryngeal carcinoma [44] and lung carcinoma [45]. The gene discussed is CD44; the disease is digestive system neuroendocrine neoplasm.