HPGDS and malignant colon neoplasm: Furthermore, the attenuation of lipopolysaccharide (LPS)-induced oxidative as well as inflammatory stress in colon cancer cells (HT-29) has been reported by downregulating TNF-α expression and upregulating the expression of heme oxygenase-1 (HO-1) and glutathione S-transferase (GSTs) detoxification genes (i.e., GSTM1, GSTT1, and GSTP1) after onion peel extract (OPE) treatments [50].