Moreover, the Transforming Growth Factor-Beta (TGF-β) signaling pathway has an important role in sarcopenia, since muscle regeneration is modulated by members of the TGF-β superfamily, one of which is myostatin, a myokine and secreted growth differentiation factor that regulates muscle growth, upregulating the ubiquitin ligases atrogin1 and MuRF1 via FoxO transcription factors [88]. Here, TGFB1 is linked to sarcopenia.