Experiments have been performed [76] where BM-MSCs were co-cultured with nasal polyp-derived cells cultures that exhibited a direct immunomodulation on nasal inflammatory polyposis that resulted in a significant increase in CD4+CD25+Foxp3+ T cells and a decrease in the frequency of CD4+, CD8+, CD14+, and NK cells, and finally promoted a strong inhibition of CD4+ and CD8+ T cell proliferation [76], where the global cytokine profile changed from an inflammatory to an anti-inflammatory response. The gene discussed is CD4; the disease is nasal cavity polyp.