Comparing Th2/Th1/Th17 cytokine patterns and markers of eosinophilic and neutrophilic inflammation in patients with CRS from six regions covering Europe, Asia, and Australia [12], higher levels of Th2 and IL-5, together to eosinophilic inflammation, are found in European patients with CRSwNP; on the other hand, neutrophilic inflammation combined with Th1/Th17 endotypes were found in southern Chinese patients. This evidence concerns the gene IL5 and congenital rubella syndrome.