HMGB1 and nasal cavity polyp: It has been shown that the PPAR-γ agonist rosiglitazone (ROG) has an inhibitory effect on HMGB1 (high mobility group box 1), a pro-inflammatory DNA-binding nuclear protein, inducing the epithelial cells to become mesenchymal-like cells and supporting the pathogenesis of eosinophilic chronic rhinosinusitis with nasal polyps ECRSwNP [49].