Indeed, a disrupted CX3CL1/CX3CR1 axis (microglial-neuron communication) is associated with increased IL1β protein levels, and the blockage of IL1-R1 was sufficient to reverse long-term potentiation (LTP) and cognitive impairments in CX3CR1 knockout mice [200]. The gene discussed is CX3CR1; the disease is Cognitive impairment.