To examine the efficacy of CPT‐11 for cell growth inhibition and p53 target gene expression, we treated MESO4 cells [in which the induction of CES2 mRNA was most prominent among the p53‐expressing MM cells tested (Fig. 1B)], with different concentrations of CPT‐11 (2.5–20 μg·mL−1). Here, TP53 is linked to Miyoshi myopathy.