A large series comparing the clinicopathological and molecular features between younger (<45 years) and older (≥45 years) GC patients [2] demonstrated that younger patients were associated with a female predominance and a more advanced stage, less frequent TP53 and HER-2 overexpression, fewer microsatellite instability-high (MSI-H) tumors, a higher level of Helicobacter pylori (HP) infection, and worse cancer-specific survival than older patients. The gene discussed is TP53; the disease is cancer.