Fourthly, curcumin also enhanced Akt phosphorylation and inhibited Foxo1 acetylation, indicating that it might reduce OS damage of type 2 diabetes and protect cardiomyocyte from apoptosis by modulating Sirt1‐Foxo1and PI3K‐Akt pathways. The gene discussed is FOXO1; the disease is type 2 diabetes mellitus.