To further explore the roles of the six m6A RNA methylation regulators (IGF2BP3, FTO, ZNF217, METTL3, YTHDC1 and YTHDC2) and 27 key genes in COPD, we analysed the relevance between six m6A RNA methylation regulators and these key genes. Here, METTL3 is linked to chronic obstructive pulmonary disease.