To further explore the roles of the six m6A RNA methylation regulators (IGF2BP3, FTO, ZNF217, METTL3, YTHDC1 and YTHDC2) and 27 key genes in COPD, we analysed the relevance between six m6A RNA methylation regulators and these key genes. This evidence concerns the gene YTHDC2 and chronic obstructive pulmonary disease.