Disease-causing variants have been reported in CNGA3,2,3CNGB3,4GNAT2,5,6ATF6,7PDE6H,8 and PDE6C.9GNAT2, ATF6, PDE6H, and PDE6C variants are responsible for approximately 2% of ACHM cases each.1 This evidence concerns the gene PDE6C and achromatopsia.