TRPV1 and neoplasm: Although LLC cell inoculation resulted in a similar tumor growth in TRPV1-knockout mice (B6.129X1-Trpv1tm1JμL/J; hereafter TRPV1-KO or TRPV1–/–) and WT mice, TRPV1–/– mice failed to develop thermal hyperalgesia in the affected limb (Figure 3G).