The inhibition of PD-L1 (10 ng/mL) on TRPV1 currents by different doses of capsaicin was greater in bone cancer mice than that in sham mice (Figure 3E, 2-way RM ANOVA, treatments: F[1, 82] = 4.11, P = 0.04). This evidence concerns the gene TRPV1 and bone cancer.