TRPV1 and cancer: Second, despite conflicting reports regarding the involvement of TRPV1 in mechanical hypersensitivity evoked by inflammatory and neuropathic pain (11, 51, 52), we observed in the present study that mechanical allodynia in cancer-bearing mice is partially attenuated in TRPV1-KO mice, and the antiallodynia of PD-L1 was eliminated in TRPV1-KO mice.