TRPV1–/– mice could still develop mechanical allodynia following the tumor inoculation, but the bone cancer–induced mechanical allodynia in TRPV1–/– mice was less than in WT mice (Figure 3H, 2-way RM ANOVA, treatment: F[1, 15] = 10.19, P = 0.002). This evidence concerns the gene TRPV1 and neoplasm.