NF1 and neoplasm: Consistent with these findings, immunostaining confirmed that the loss of Nf1 in H7;Lats1/2mut3 tumor enhanced the expression of p-ERK, a RAS/MAPK pathway activation marker (Figure 6D and Supplemental Figure 7B), and these tumors were well circumscribed with hypercellular (Antoni A) areas and hypocellular (Antoni B) areas of predominantly organized Schwann cells, consistent with schwannomas histologically and molecularly (Supplemental Figure 8).