By comparing our data with published transcriptome data sets from human BM neutrophils and purified SLE LDN populations, we have found that immature neutrophils D1/D3 Hoxb8, human BM metamyelocytes, band neutrophils, and CD10– SLE LDNs all exhibited high CYBB expression, which suggests an enhanced capacity for superoxide production. Here, HOXB8 is linked to systemic lupus erythematosus.