While many of these genes showed similar expression between immature and mature neutrophils from Hoxb8 neutrophils, human BM neutrophils and SLE LDN — some, such as SRXN1, TXNRD1, SOD2, and HMOX1/2, were highly expressed only in mature neutrophils from mouse to human (Supplemental Figure 5). This evidence concerns the gene HOXB8 and systemic lupus erythematosus.