Furthermore, Serum Prolactin concentrations in high dose Chlorpromazine and Reserpine treated groups (C and E) were highly significantly increased, and this report is in line with Ben-Jonathan & Hnasko (2001), who reported that dopamine depletion reaching the lactotroph cells resulted in hyperprolactinemia, which always has negative feedback on hypothalamic GnRH secretion. The gene discussed is GNRH1; the disease is hyperprolactinemia.