While the complete roles of TOPK in chordoma are unknown, several studies have shown that TOPK is a prognostic marker of poor outcomes in lung cancer, ovarian cancer, kidney cancer, colorectal cancer, leukaemia, melanoma and glioblastoma.11, 14, 15, 16, 17, 18, 19, 31. This evidence concerns the gene PBK and ovarian carcinoma.