While the complete roles of TOPK in chordoma are unknown, several studies have shown that TOPK is a prognostic marker of poor outcomes in lung cancer, ovarian cancer, kidney cancer, colorectal cancer, leukaemia, melanoma and glioblastoma.11, 14, 15, 16, 17, 18, 19, 31. The gene discussed is PBK; the disease is chordoma.