In this study, we investigated the gastric tumor response to radiation therapy, based on the Sting signal, IFNB1, TNFα, CXCL-9 as well as IL-10 gene expression, infiltration of DCs, Th and Teff cells in the tumor microenvironment, and PD-1/PD-L1 expression after radiation therapy. This evidence concerns the gene IL10 and gastric neoplasm.