CCR2 and experimental autoimmune encephalomyelitis: As a positive control, we crossed Siglechdtr with Ccr2RFP mice to label CCR2+ cells with red fluorescent protein (RFP) and confirmed that a large number of RFP+ cells infiltrated the spinal cord of Siglechdtr/dtr:Ccr2RFP/+ mice after induction of experimental autoimmune encephalomyelitis (EAE; Fig 2A).