In contrast, immunofluorescence staining for LAMP1 (Fig 6C) and relative quantification (Fig 6D) showed increased LAMP1 density in the striatum of R6/2 ACSF mice and in the contralateral striatum of R6/2 chol‐high compared to wt mice, suggesting an accumulation of lysosomes in HD cells. This evidence concerns the gene LAMP1 and Huntington disease.