TNF and metabolic syndrome: However, KDM6A encodes demethylase UTX, which erases the repressing H3K27Me3 signature (Allis, Caparros, Jenuwein, & Reinberg, 2015), whose expression levels and the levels of EIF1AX, DDX3X, and CD99 are associated with an increased abdominal circumference among KS patients and with serum IL‐6, TNF, C‐reactive protein, and procoagulant plasminogen activator inhibitor 1 (PAI‐1) levels, which are potentially associated with an increased risk of metabolic syndrome among KS patients (Zitzmann et al., 2015).