Western blot analysis showed that CB11 induced the expression of p-ATM, p-chk2, and cleaved caspase-3 in control NSCLC cells; however, ATM inhibition inhibited CB11-mediated ATM and chk2 phosphorylation and cleavage of caspase-3 (Supplementary Fig. 2B). This evidence concerns the gene CASP3 and non-small cell lung carcinoma.