Secretions of the chemokines CXCL1 and CCL3 were significantly higher in infected ECD mice compared to infected control mice one-week post infection (p < 0.0001) (Supplementary Fig. S3A,B), there was a decrease in the chemokine levels by 2 weeks post infection, which is like the trend observed for mice infected at ZT3. This evidence concerns the gene CXCL1 and infection.