TINF2 and pancolitis: Along these lines, our own data on patients with germline mutations in telomere-related proteins as well as a recent study of the gastrointestinal manifestations in younger patients with mutations in TERT, TIN2, TRF2, or TR genes revealed significant pancolitis, villous atrophy, crypt dropout and intraepithelial lymphocytosis as the most common lower GI tract manifestations7.