Generally, when considering all MC3 and all PCAWG mutations separately, we observed that PCAWG variant matching rates were generally higher, especially for Kidney Chromophobe (KICH), Brain Lower Grade Glioma (LGG), Ovarian Serous Cystadenocarcinoma (OV), Rectum Adenocarcinoma (READ), and Thyroid Carcinoma (THCA). The gene discussed is MC3R; the disease is thyroid gland carcinoma.