MC3R and cancer: Furthermore, after accounting for hypermutators, we identified a correlation between non-silent mutations per megabase and mean consensus percentages at the cancer level in both PCAWG consensus percentages (Mann–Whitney p-value = 1.97 × 10−3) and MC3 consensus percentages (Mann–Whitney p-value = 6.59 × 10−4, see “Methods” section, Supplementary Fig. 1c, d).