PIK3CA and cancer: After removing two outlier samples having excesses of unique mutations (TCGA-CA-6717-01A-11D-1835-10, TCGA-BR-6452-01A-12D-1800-08), we observed 424 mutations in cancer genes28 (median read depth = 97, median alternative allele count = 9) The four most frequently mutated genes were: KMT2C (22-mutations), PIK3CA (12), SPTA1 (9), and NCOR1 (9).