Generally, when considering all MC3 and all PCAWG mutations separately, we observed that PCAWG variant matching rates were generally higher, especially for Kidney Chromophobe (KICH), Brain Lower Grade Glioma (LGG), Ovarian Serous Cystadenocarcinoma (OV), Rectum Adenocarcinoma (READ), and Thyroid Carcinoma (THCA). Here, MC3R is linked to rectum adenocarcinoma.