The role of canonical NF-κB in cancer is complex, with either positive or negative effects in initiation and progression of cancer.183,223 Activation of canonical NF-κB is a reaction of host defense for pathogen elimination,39,224 on the other hand, activation of canonical NF-κB promotes proliferation, survival, angiogenesis and invasion of tumor cells, contributing to tumor promotion and progression.183,225 Here we mainly discuss the tumor-promoting effect of canonical NF-κB and correlation between inflammation and cancer. Here, NFKB1 is linked to neoplasm.