PELI1 and psoriasis: CRL4DCAF2 is a critical E3 ligase in cell cycle and mitotic and S phase progression.282,283 CRL4DCAF2 promotes NIK degradation independent of TRAF-cIAP, which further inhibits IL-23 production in dendritic cells and suppresses the development of psoriasis.280 Peli1 functions in many signaling pathways in innate immune cells and T-cells.284–286 Like CRL4DCAF2, Peli1 interacts with NIK and mediates K48-linked ubiquitination and degradation of NIK.