Mechanism studies indicate NLRP12 interacts with both TRAF3 and NIK, affecting their stability (Fig. 2).294 NLRP12 deficiency results in hyperactivation of non-canonical NF-κB and the overexpression of chemokines CXCL12 and CXCL13, which are crucial for colonic inflammation and tumorigenesis in the DSS-induced colitis and colorectal cancer (CRC) model. The gene discussed is NLRP12; the disease is colorectal cancer.