Furthermore, activating mutations of GNAS affecting Gαs lead to McCune-Albright syndrome (post-zygotic mosaicism) and acromegaly (somatic mutations), while activating mutations of the thyrotropin-stimulating hormone (TSH) and luteinizing hormone (LH) receptor are associated with diseases such as hyperfunctioning thyroid adenoma and familial male precocious puberty, respectively54,55. This evidence concerns the gene GNAS and McCune-Albright syndrome.