CMA1 and bacterial infectious disease with sepsis: In the context of rising bacteremia by day 4 p.i. that was significant by day 6 p.i. (Fig. 1B), significantly increased numbers of MCs, identified using naphthol AS-D chloroacetate esterase (NASDCE) activity, which specifically detects MC secretory granule chymases, were observed in the ileum by days 4 and 8 p.i. relative to controls (Fig. 3A and B).