In this study, we further demonstrated the novel function of REC8 in tumor angiogenesis by activation of NF-κB-VEGF-mediated recruitment of HUVECs and tube formation, inhibition of NF-κB by NF-κB inhibitor BAY11-7082 significantly revered the promotion of CM from REC8-depleted gastric cancer cells on tube formation, which would be required to confirm in vivo. Here, VEGFA is linked to neoplasm.