PSEN1 and Alzheimer disease: In this study, we demonstrate that exogenous BHB administration to mice carrying human presenilin 1 (PSEN1) and amyloid precursor protein (APP) with 5 familial AD mutations under the CD90 promoter, which deposit Aβ plaques [23] (5XFAD mice), decreases overall AD pathology through inhibition of the inflammasome.