Moreover, the newly generated mouse model A20ZF7-CC/ZF7-CC (knock-in mice expressing A20 with dual cysteine-to-alanine mutations in ZnF7) has been found to have markedly increased memory phenotype T cells, which are capable of sustaining synovitis and promoting osteoclast differentiation in RA patients [28, 61]. Here, TNFAIP3 is linked to rheumatoid arthritis.