Studies have established that rs2230926: T > G is strongly associated with RA [94, 96]; this SNP is found to result in a change from phenylalanine to cysteine at position 127, which encodes A20 protein’s deubiquitinase domain and can result in a decreased ability of A20 to suppress NF-κB activation [92]. This evidence concerns the gene NFKB1 and rheumatoid arthritis.