Since then, several A20-associated mouse models have been developed, and they have helped demonstrated the exact relationship between A20 and arthritis; such mouse models include the following: A20myel-KO, targeting myeloid cells [21], A20mZnF7/mZnF7, targeting the ZnF7 motif, and A20ZF4ZF7, targeting ZnF4 and ZnF7 motifs [29]. This evidence concerns the gene ZNF7 and arthritic joint disease.