The Bax and bcl-2 are the most commonly used proteins to detect apoptosis, SKOV-3 is ovarian cancer cell line with high expression of VEGFR-2, and AP can inhibit tumor angiogenesis by inhibiting the formation of p-VEGFR-2, and MMP-2 is closely related to the ability of invasion of tumor cell. The gene discussed is MMP2; the disease is ovarian cancer.