Moreover, luciferase analysis demonstrated that KLF12 was directly regulated by miR-141, and overexpression of KLF12 in miR-141 mimic-transfected HUVECs abrogated the proangiogenic effect of miR-141, thereby confirming that miR-141 promotes SCLC tumor angiogenesis by targeting KLF12. This evidence concerns the gene KLF12 and small cell lung carcinoma.