To test the five-TF based signature as colon cancer survival predictor, we further validated the predictive model on another four independent microarray datasets with a total of 1584 samples for GEO with GSE39582 (n = 563), GSE17536 (n = 177), GSE37892 (n = 130) and GSE17537 (n = 55). Here, TF is linked to malignant colon neoplasm.