RAPGEF1 and chronic kidney disease: In this gene-gene correlation disruption network, 44 of 83 total edges were connected to five differentially coexpressed genes from Signaling events mediated by focal adhesion kinase, namely ACTN4, ARHGAP26, MYLK, RAPGEF1, and WASL. As the hub of Signaling events mediated by focal adhesion kinase in early CKD, ACTN4 lost its hub status in late CKD (Table 1), and decreased its correlation with genes from all seven linked pathways but Validated targets of C-MYC transcriptional repression.