In concordance with this global trend of correlation attenuation, 43 genes lost their hub statuses established in early CKD transcriptomes, including ACTN4, ARF6, MAP2K7, and SRCAP. Moreover, the pathway Signaling events mediated by focal adhesion kinase displayed significantly weakened crosstalk with seven pathways, including Regulation of nuclear SMAD2/3 signaling. This evidence concerns the gene ACTN4 and chronic kidney disease.