In one recent study, the TERT-mut/MGMT-unmeth GBM was associated with worse magnetic resonant imaging (MRI) characteristics such as low apparent diffusion coefficient values, obvious edema, obvious necrosis, unobvious non-contrast enhancing tumor, deep white matter invasion, and a high Ki-67 labeling rather than other groups [10]. The gene discussed is TERT; the disease is glioblastoma.