From our results, the OS of gliomas can be further stratified into four distinct survival subgroups with ascending survival time as follow: TERT-mut/MGMT-unmeth << TERT-wt/MGMT-unmeth << TERT-wt/MGMT-meth << TERT-mut/MGMT-meth which is consistent with previous reports [16, 26]. Here, TERT is linked to central nervous system cancer.