PKD2 mutation causes end-stage renal disease at an average age of 74 years, which occurs in 10–15% of cases; on the other hand, PKD1 mutation results in end-stage renal disease at an average age of 54 years which occurs in 80–90% of total cases of ADPKD. The gene discussed is PKD1; the disease is autosomal dominant polycystic kidney disease.